Gt(ROSA)26Sor^{tm2.1(luc*/Arrb2*)Rlp}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2.1(luc*/Arrb2*)Rlp}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2.1, Richard L Proia
• MGI ID: MGI:6315195
• Synonyms: NLuc-beta-arrestin2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2.1(luc*/Arrb2*)Rlp} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254567
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct is designed to insert a floxed neomycin resistance (neo) cassette followed by the N-terminal luciferase fragment (amino acids 1-416) into the N-terminus of the Arrb2 gene. Cre-mediated recombination removed the upstream floxed neo cassette. (J:254567)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 956 strains or lines available

Notes

ES cell line BA1

References

• Original: J:254567 Kono M, et al., Bioluminescence imaging of G protein-coupled receptor activation in living mice. Nat Commun. 2017 Oct 27;8(1):1163
• All: 1 reference(s)