S1pr1^tm4.1Rlp
Targeted Allele Detail

Summary

• Symbol: S1pr1^tm4.1Rlp
• Name: sphingosine-1-phosphate receptor 1; targeted mutation 4.1, Richard L Proia
• MGI ID: MGI:6315193
• Synonyms: S1P1-CLuc
• Gene: S1pr1 Location: Chr3:115504082-115508704 bp, - strand Genetic Position: Chr3, 50.0 cM
• Alliance: S1pr1^tm4.1Rlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254567
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct is designed to insert the C terminal portion of S1pr1 fused to a C-terminal luciferase fragment (amino acids 394-550) with a polyadenylation signal, followed by a floxed neomycin resistance (neo) cassette, into the C-terminus of the S1pr1 gene. Cre-mediated recombination removed the floxed neo cassette. (J:254567)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any S1pr1 Mutation: 30 strains or lines available

Notes

ES cell line BA1

References

• Original: J:254567 Kono M, et al., Bioluminescence imaging of G protein-coupled receptor activation in living mice. Nat Commun. 2017 Oct 27;8(1):1163
• All: 1 reference(s)