Htr1a^tm1.1Stak
Targeted Allele Detail

Summary

• Symbol: Htr1a^tm1.1Stak
• Name: 5-hydroxytryptamine (serotonin) receptor 1A; targeted mutation 1.1, Takeshi Sakurai
• MGI ID: MGI:6314569
• Synonyms: Htr1a^f, Htr1a^flox deltaNEO
• Gene: Htr1a Location: Chr13:105580147-105584630 bp, + strand Genetic Position: Chr13, 56.92 cM
• Alliance: Htr1a^tm1.1Stak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275172
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The coding region of the gene was flanked by loxP sites. A frt-flanked PGK-Neo cassette was also inserted in the coding region. Flp-mediated recombination removed the neo cassette. (J:275172)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr1a Mutation: 25 strains or lines available

References

• Original: J:275172 Saito YC, et al., Serotonergic Input to Orexin Neurons Plays a Role in Maintaining Wakefulness and REM Sleep Architecture. Front Neurosci. 2018;12:892
• All: 1 reference(s)