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Ccr2tm1(cre/ERT2,mKate2)Arte
Targeted Allele Detail
Summary
Symbol: Ccr2tm1(cre/ERT2,mKate2)Arte
Name: C-C motif chemokine receptor 2; targeted mutation 1, TaconicArtemis
MGI ID: MGI:6314378
Synonyms: Ccr2tm2982(T2A-Cre/ESR1-T2A-mKate2)Arte
Gene: Ccr2  Location: Chr9:123901987-123913594 bp, + strand  Genetic Position: Chr9, 75.05 cM, cytoband F
Alliance: Ccr2tm1(cre/ERT2,mKate2)Arte page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:233647
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Ccr2tm1(cre/ERT2,mKate2)Arte expression driven by 1 gene
 
Mutation detailsA targeting vector containing an FRT-flanked puromycin resistance gene upstream of exon 3, followed by T2A, a Cre recombinase/ERT2 fusion, a second T2A sequence, and the monomeric far-red fluorescent protein mKate2 was inserted into the 3' UTR (downstream of exon 3) of the Ccr2 gene. (J:233647)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ccr2 (mouse)
Summary of all recombinase alleles driven by Ccr2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccr2 Mutation:  41 strains or lines available
References
Original:  J:233647 Croxford AL, et al., The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity. Immunity. 2015 Sep 15;43(3):502-14
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory