Esr2^em1Gust
Endonuclease-mediated Allele Detail

Summary

• Symbol: Esr2^em1Gust
• Name: estrogen receptor 2 (beta); endonuclease-mediated mutation 1, Jan-Ake Gustafsson
• MGI ID: MGI:6314275
• Synonyms: ERbeta^crispr-
• Gene: Esr2 Location: Chr12:76167193-76224033 bp, - strand Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
• Alliance: Esr2^em1Gust page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: All 10 exons were deleted by CRISPR/Cas9 genome editing technology. The mutation is a 59-kb deletion, including all gene exons and the proximal promoter. (J:285743)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esr2 Mutation: 35 strains or lines available

References

• Original: J:285743 Warner M, et al., Ventral prostate and mammary gland phenotype in mice with complete deletion of the ERbeta gene. Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4902-4909
• All: 5 reference(s)