Rgs8^em2(IMPC)H
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rgs8^em2(IMPC)H
• Name: regulator of G-protein signaling 8; endonuclease-mediated mutation 2, Harwell
• MGI ID: MGI:6306630
• Gene: Rgs8 Location: Chr1:153528612-153573415 bp, + strand Genetic Position: Chr1, 65.41 cM, cytoband G2
• Alliance: Rgs8^em2(IMPC)H page
• IMPC: Rgs8 gene page

Mutation origin

• Strain of Origin: C57BL/6NTac
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at Medical Research Council Harwell using Cas9 and guides with spacer sequences AGAGCCTCAACACACTAAGC, GCCTCGGCTCAAGGCGCAAT, GTTGTCAAGTACGTAGAATC, and TATTGACCTATCTTGGTTAC that targeted exon(s) ENSMUSE00000427126.4. This resulted in deletion(s) of 7 bp (location: Chr1:153546837-153546843; GRCm39), 109 bp (location: Chr1:153546863-153546971; GRCm39), and 1038 bp (location: Chr1:153546975-153548012; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rgs8 Mutation: 19 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 2 reference(s)