Dbhtm3.2(cre)Pjen
Targeted Allele Detail
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Symbol: |
Dbhtm3.2(cre)Pjen |
Name: |
dopamine beta hydroxylase; targeted mutation 3.2, Patricia Jensen |
MGI ID: |
MGI:6305870 |
Synonyms: |
Dbhcre |
Gene: |
Dbh Location: Chr2:27055519-27073216 bp, + strand Genetic Position: Chr2, 19.29 cM
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Alliance: |
Dbhtm3.2(cre)Pjen page
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Dbhtm3.2(cre)Pjen expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Dbh (MGI:94864) |
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Mutation details: A rox-flanked transcriptional stop cassette, cre cDNA, rabbit beta-globin polyadenylation cassette, and attB/attP-flanked neomycin resistance cassette were inserted into the Dbh locus, immediately following the start codon by homologous recombination. A recombinant clone was transiently transfected with pPGKPhiC31obpa to excise the neomycin resistance cassette before cells were injected into blastocysts to produce chimeric mice. Following germline transmission, heterozygotes were crossed with Dre expressing mice to remove the rox-flanked stop cassette.
(J:285301)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Dbh
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:285301 Tillage RP, et al., Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviors. Brain Struct Funct. 2020;225(2):785-803 |
All: |
2 reference(s) |
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