Macroh2a1^tm1.1Pobe
Targeted Allele Detail

Summary

• Symbol: Macroh2a1^tm1.1Pobe
• Name: macroH2A.1 histone; targeted mutation 1.1, Philipp Oberdoerffer
• MGI ID: MGI:6305064
• Gene: Macroh2a1 Location: Chr13:56221435-56283439 bp, - strand Genetic Position: Chr13, 30.06 cM, cytoband B2
• Alliance: Macroh2a1^tm1.1Pobe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297180
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 6a was floxed for conditional inactivation of the macroH2A1.2 splice isoform. Cre-mediated recombination removed the selection cassette. (J:297180)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Macroh2a1 Mutation: 49 strains or lines available

References

• Original: J:297180 Sebastian R, et al., Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability. Mol Cell. 2020 Sep 3;79(5):836-845.e7
• All: 1 reference(s)