Tg(Myh6-Mybpc3)2/1Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6-Mybpc3)2/1Rbns
• Name: transgene insertion 2/1, Jeffrey Robbins
• MGI ID: MGI:6304491
• Synonyms: MyBP-C.wt
• Transgene: Tg(Myh6-Mybpc3)2/1Rbns Location: unknown
• Alliance: Tg(Myh6-Mybpc3)2/1Rbns page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene comprises the following elements: the mouse Myh6 promoter, sequence for the human Myc epitope tag immediately after the ATG start codon, the wild-type mouse Mybpc3 cDNA, and human GH gene poly(A) signal sequence. Three mouse lines (3/1, 1/3, 2/1) were established; line 2/1 was the highest expressing line (approximately 4.5x endogenous mRNA level) and was used for further experiments. (J:50237)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:50237 Yang Q, et al., A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy. J Clin Invest. 1998 Oct 1;102(7):1292-300
• All: 7 reference(s)