Nlrp12^tm1Macha
Targeted Allele Detail

Summary

• Symbol: Nlrp12^tm1Macha
• Name: NLR family, pyrin domain containing 12; targeted mutation 1, Mathias Chamaillard
• MGI ID: MGI:6304240
• Gene: Nlrp12 Location: Chr7:3267458-3298370 bp, - strand Genetic Position: Chr7, 1.88 cM
• Alliance: Nlrp12^tm1Macha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268356
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin-resistance cassette replaced the first two exons of the gene. The absence of encoded mRNA in homozygous animals was confirmed by quantitative reverse-transcriptase (RT)-qPCR. (J:268356)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp12 Mutation: 52 strains or lines available

References

• Original: J:268356 Normand S, et al., Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens. Nat Commun. 2018 Dec 17;9(1):5338
• All: 1 reference(s)