Stra8^em2Dcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Stra8^em2Dcp
• Name: stimulated by retinoic acid gene 8; endonuclease-mediated mutation 2, David C Page
• MGI ID: MGI:6303965
• Synonyms: Stra8^delta121
• Gene: Stra8 Location: Chr6:34897098-34916279 bp, + strand Genetic Position: Chr6, 15.2 cM
• Alliance: Stra8^em2Dcp page

Mutation origin

• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: Using an sgRNA and CRISPR/Cas9 technology, a repair of the double strand break with non-homologous end joining, resulting in a 121 bp deletion in Stra8 gene lacking the long isoform was generated. (J:273739)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stra8 Mutation: 34 strains or lines available

References

• Original: J:273739 Kojima ML, et al., Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice. Elife. 2019 Feb 27;8:e43738
• All: 1 reference(s)