Map4k1^tm1.1Jinl
Targeted Allele Detail

Summary

• Symbol: Map4k1^tm1.1Jinl
• Name: mitogen-activated protein kinase kinase kinase kinase 1; targeted mutation 1.1, Jinqi Liu
• MGI ID: MGI:6303744
• Synonyms: HPK1 KD
• Gene: Map4k1 Location: Chr7:28681506-28702704 bp, + strand Genetic Position: Chr7, 16.94 cM, cytoband A3
• Alliance: Map4k1^tm1.1Jinl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274583
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Single point mutation
• Mutation details: A point mutation was engineered in exon 2, changing lysine codon 46 to methionine (p.K46M). The FRT site flanked puromycin resistance gene cassette that was inserted into intron 5 was removed through subsequent flp-mediated recombination. The amino-acid substitution in the kinase domain of the encoded peptide creates a kinase-dead protein. (J:274583)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map4k1 Mutation: 56 strains or lines available

References

• Original: J:274583 Liu J, et al., Critical role of kinase activity of hematopoietic progenitor kinase 1 in anti-tumor immune surveillance. PLoS One. 2019;14(3):e0212670
• All: 1 reference(s)