Rnf168^tm1Nus
Targeted Allele Detail

Summary

• Symbol: Rnf168^tm1Nus
• Name: ring finger protein 168; targeted mutation 1, Andre Nussenzweig
• MGI ID: MGI:6296662
• Synonyms: RNF168^-
• Gene: Rnf168 Location: Chr16:32096277-32120252 bp, + strand Genetic Position: Chr16, 22.51 cM, cytoband B2
• Alliance: Rnf168^tm1Nus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274082
• Parent Cell Line: JM8A3.N1.C2 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance gene cassette was inserted into exon 2, creating a knockout allele. (J:274082)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf168 Mutation: 70 strains or lines available

References

• Original: J:274082 Zong D, et al., BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation. Mol Cell. 2019 Mar 21;73(6):1267-1281.e7
• All: 1 reference(s)