Nek1^em4Lutzy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nek1^em4Lutzy
• Name: NIMA (never in mitosis gene a)-related expressed kinase 1; endonuclease-mediated mutation 4, Cathy Lutz
• MGI ID: MGI:6295429
• Synonyms: Nek1^R261H
• Gene: Nek1 Location: Chr8:61446229-61584380 bp, + strand Genetic Position: Chr8, 30.91 cM
• Alliance: Nek1^em4Lutzy page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 genome editing is used to introduce an R261H amino acid substitution. In humans, the R261H substitution is associated with motor neuron disease. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nek1 Mutation: 84 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)