Abca12^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Abca12^em1(IMPC)J
• Name: ATP-binding cassette, sub-family A member 12; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6294780
• Gene: Abca12 Location: Chr1:71282249-71454069 bp, - strand Genetic Position: Chr1, 35.81 cM
• Alliance: Abca12^em1(IMPC)J page
• IMPC: Abca12 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences AGTGCTTAGATTGCCCCCAA and TTAGTCAACTGAAATTAATG, which resulted in a 254 bp deletion beginning at Chromosome 1 position 71,353,549 bp and ending after 71,353,802 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000441018 (exon 4) and 162 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 106 and early truncation 8 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Abca12 Mutation: 131 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)