Ush1g^em1Ykkw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ush1g^em1Ykkw
• Name: USH1 protein network component sans; endonuclease-mediated mutation 1, Yoshiaki Kikkawa
• MGI ID: MGI:6294281
• Synonyms: Cdh23^c.753G
• Gene: Ush1g Location: Chr11:115206018-115212867 bp, - strand Genetic Position: Chr11, 80.84 cM
• Alliance: Ush1g^em1Ykkw page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting of exon 7 produced an A to G point mutation at position 753 to mimic the point mutation in Ush1g^js mice. (J:235883)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ush1g Mutation: 17 strains or lines available

References

• Original: J:235883 Miyasaka Y, et al., Heterozygous mutation of Ush1g/Sans in mice causes early-onset progressive hearing loss, which is recovered by reconstituting the strain-specific mutation in Cdh23. Hum Mol Genet. 2016 May 15;25(10):2045-2059
• All: 1 reference(s)