Insr^tm1Tka
Targeted Allele Detail

Summary

• Symbol: Insr^tm1Tka
• Name: insulin receptor; targeted mutation 1, Takashi Kadowaki
• MGI ID: MGI:6294280
• Synonyms: IR^lox
• Gene: Insr Location: Chr8:3200922-3329649 bp, - strand Genetic Position: Chr8, 1.82 cM
• Alliance: Insr^tm1Tka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267724
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 4. (J:267724)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Insr Mutation: 95 strains or lines available

References

• Original: J:267724 Kubota T, et al., Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity. Nat Commun. 2018 Nov 19;9(1):4863
• All: 1 reference(s)