Tfap4^tm1.2Hher
Targeted Allele Detail

Summary

• Symbol: Tfap4^tm1.2Hher
• Name: transcription factor AP4; targeted mutation 1.2, Heiko Hermeking
• MGI ID: MGI:6294262
• Gene: Tfap4 Location: Chr16:4362525-4377718 bp, - strand Genetic Position: Chr16, 2.45 cM, cytoband A1
• Alliance: Tfap4^tm1.2Hher page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267749
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were floxed. Flp-mediated recombination removed the FRT-flanked selection cassette. Cre-mediated recombination removed exons 2 through 4. (J:267749)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfap4 Mutation: 92 strains or lines available

References

• Original: J:267749 Jaeckel S, et al., Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells. Nat Commun. 2018 Sep 3;9(1):3573
• All: 3 reference(s)