Kcnq3^em3(IMPC)H
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnq3^em3(IMPC)H
• Name: potassium voltage-gated channel, subfamily Q, member 3; endonuclease-mediated mutation 3, Harwell
• MGI ID: MGI:6293856
• Gene: Kcnq3 Location: Chr15:65858236-66158491 bp, - strand Genetic Position: Chr15, 29.16 cM
• Alliance: Kcnq3^em3(IMPC)H page
• IMPC: Kcnq3 gene page

Mutation origin

• Strain of Origin: C57BL/6NTac
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at Medical Research Council Harwell using Cas9 and 4 guides with spacer sequences ACCACTGGACCCAATTCTCA, GTGAAGAGTGCCAAAATATC, and TAGTCCTGACACTGGATACT that targeted exon(s) ENSMUSE00000484191.2. This resulted in deletion(s) of 2 bp (location: Chr15:65902278-65902279; GRCm39), 317 bp (location: Chr15:65902358-65902674; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnq3 Mutation: 53 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 2 reference(s)