Mir27a^em1Bge
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir27a^em1Bge
• Name: microRNA 27a; endonuclease-mediated mutation 1, Baoxue Ge
• MGI ID: MGI:6287970
• Synonyms: miR-27a^-, miR-27a KO
• Gene: Mir27a Location: Chr8:84935301-84935387 bp, + strand Genetic Position: Chr8, 40.58 cM
• Alliance: Mir27a^em1Bge page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a frameshift mutation. No further details were specified. qPCR analysis demonstrated a dramatic reduction of Mir27a expression in the lung of homozygous mutant mice. (J:267961)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir27a Mutation: 2 strains or lines available

References

• Original: J:267961 Liu F, et al., MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy. Nat Commun. 2018 Oct 16;9(1):4295
• All: 2 reference(s)