Mecom^tm3.1Aspe
Targeted Allele Detail

Summary

• Symbol: Mecom^tm3.1Aspe
• Name: MDS1 and EVI1 complex locus; targeted mutation 3.1, Archibald Perkins
• MGI ID: MGI:6287968
• Synonyms: Evi1^TO
• Gene: Mecom Location: Chr3:30005445-30563937 bp, - strand Genetic Position: Chr3, 12.66 cM
• Alliance: Mecom^tm3.1Aspe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268072
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The targeting construct introduced into exon 1 an FRT-flanked neomycin resistance cassette and STOP sequence followed by seven tet operons. Flp-mediated recombination removed the selection cassette and STOP sequence. The resulting allele is tetracycline-induced. (J:268072)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mecom Mutation: 81 strains or lines available

References

• Original: J:268072 Ayoub E, et al., EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription. Nat Commun. 2018 Oct 12;9(1):4239
• All: 1 reference(s)