Casp1^em1Ogrs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Casp1^em1Ogrs
• Name: caspase 1; endonuclease-mediated mutation 1, Olaf Gross
• MGI ID: MGI:6287840
• Gene: Casp1 Location: Chr9:5298517-5307281 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Casp1^em1Ogrs page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR-targeting of exon 5 produced a TT insertion that leads to translation stop codon and BsrGI restriction site. (J:268223)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp1 Mutation: 43 strains or lines available

References

• Original: J:268223 Schneider KS, et al., The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity. Cell Rep. 2017 Dec 26;21(13):3846-3859
• All: 2 reference(s)