Casp1^tm2.1Ogrs
Targeted Allele Detail

Summary

• Symbol: Casp1^tm2.1Ogrs
• Name: caspase 1; targeted mutation 2.1, Olaf Gross
• MGI ID: MGI:6287839
• Synonyms: Casp1^mtl
• Gene: Casp1 Location: Chr9:5298517-5307281 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Casp1^tm2.1Ogrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268223
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Codon 284 was altered from GCATGCCGT to GCAGCGCGT. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted between exon 7 and 8. (J:268223)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp1 Mutation: 43 strains or lines available

References

• Original: J:268223 Schneider KS, et al., The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity. Cell Rep. 2017 Dec 26;21(13):3846-3859
• All: 1 reference(s)