Igh^{tm1(Igh564)Tik}
Targeted Allele Detail

Summary

• Symbol: Igh^{tm1(Igh564)Tik}
• Name: immunoglobulin heavy chain complex; targeted mutation 1, Thereza Imanishi-Kari
• MGI ID: MGI:6287435
• Synonyms: IgH564
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance gene, as well as the VDJ 564 region from a hybridoma derived from an autoimmune SWRxNZB mouse, replaced a segment of DNA including DQ52 and the entire JH region. (J:113555)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 45 strains or lines available

Notes

The version of this allele that does not contain the neomycin selection cassette, Igh^{tm1.1(Igh564)Tik}, has been analyzed.

References

• Original: J:113555 Berland R, et al., Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice. Immunity. 2006 Sep;25(3):429-40
• All: 7 reference(s)