Il17rc^tm1.1Lix
Targeted Allele Detail

Summary

• Symbol: Il17rc^tm1.1Lix
• Name: interleukin 17 receptor C; targeted mutation 1.1, Xiaoxia Li
• MGI ID: MGI:6287262
• Gene: Il17rc Location: Chr6:113448416-113460124 bp, + strand Genetic Position: Chr6, 52.77 cM, cytoband E3
• Alliance: Il17rc^tm1.1Lix page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272898
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the selection cassette and left exons 6 and 7 floxed. (J:272898)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17rc Mutation: 34 strains or lines available

References

• Original: J:272898 Bulek K, et al., IL-17A Recruits Rab35 to IL-17R to Mediate PKCalpha-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility. J Immunol. 2019 Mar 1;202(5):1540-1548
• All: 2 reference(s)