Mitf^{Tg(Tff3-Tmem207)2Tamo}
Transgenic Allele Detail

Summary

• Symbol: Mitf^{Tg(Tff3-Tmem207)2Tamo}
• Name: melanogenesis associated transcription factor; transgene insertion 2, Takeuchi Tamotsu
• MGI ID: MGI:6287154
• Synonyms: Tg(ITF-TMEM207)
• Gene: Mitf Location: Chr6:97784013-97998310 bp, + strand Genetic Position: Chr6, 45.05 cM
• Alliance: Mitf^{Tg(Tff3-Tmem207)2Tamo} page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mitf^{Tg(Tff3-Tmem207)2Tamo} expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tmem207 (MGI:2685386)

• Mutation details: The proximal promoter of the murine Tff3 gene (lacking a goblet cell silencer inhibitor element) drives the expression of the full coding region of the murine Tmem207 gene. A genome walking assay revealed that the transgene inserted into a basic helix-loop-helix leucine zipper region of Mitf. Western blot analysis indicates that a lower level of Mitf protein is expressed in the brain than in wild-type mice. No line number is given, however this line was named 2 to distinguish between this line in which the transgene inserted in chromosome 6 and other lines that were created including line 1 that inserted in chromosome 2. (J:244533)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mitf Mutation: 74 strains or lines available

References

• Original: J:244533 Kito Y, et al., Novel Transgenic Mouse Model of Polycystic Kidney Disease. Am J Pathol. 2017 Sep;187(9):1916-1922
• All: 1 reference(s)