Mchr1^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Mchr1^M1Btlr
• Name: melanin-concentrating hormone receptor 1; mutation 1, Bruce Beutler
• MGI ID: MGI:6286319
• Synonyms: Ketogenic
• Gene: Mchr1 Location: Chr15:81119700-81123165 bp, + strand Genetic Position: Chr15, 38.02 cM
• Alliance: Mchr1^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 81,237,868 (v38) on chromosome 15, or base pair 2,370 in the GenBank genomic region NC_000081. The mutation corresponds to residue 1,093 in the mRNA sequence NM_145132 within exon 2 of 2 total exons. The mutation results in a tyrosine to cysteine substitution at position 273 (Y273C) in the MCHR1 protein. (J:272868)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mchr1 Mutation: 24 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3602

References

• Original: J:272868 Zhang Z, et al., Mutagenetix entry for Ketogenic. MGI Direct Data Submission. 2019
• All: 1 reference(s)