Pappa^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Pappa^M2Btlr
• Name: pregnancy-associated plasma protein A; mutation 2, Bruce Beutler
• MGI ID: MGI:6286275
• Synonyms: Maennel
• Gene: Pappa Location: Chr4:65042411-65275746 bp, + strand Genetic Position: Chr4, 34.14 cM
• Alliance: Pappa^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 65,314,587 (v38) on chromosome 4, or base pair 190,414 in the GenBank genomic region NC_000070. The mutation corresponds to residue 4,330 in the mRNA sequence NM_021362 within exon 16 of 22 total exons. The mutation results in an asparagine to serine substitution at position 1,321 (N1321S) in the PAPP-A protein. (J:272860)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pappa Mutation: 71 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3803

References

• Original: J:272860 Zhang Z, et al., Mutagenetix entry for Maennel. MGI Direct Data Submission. 2019
• All: 1 reference(s)