Rag1^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Rag1^m3Btlr
• Name: recombination activating 1; mutation 3, Bruce Beutler
• MGI ID: MGI:6286258
• Synonyms: dysfunctional
• Gene: Rag1 Location: Chr2:101468627-101479846 bp, - strand Genetic Position: Chr2, 53.88 cM
• Alliance: Rag1^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to T transition at base pair 101,644,284 (v38) on chromosome 2, or base pair 5,249 in the GenBank genomic region NC_000068. The mutation corresponds to residue 637 in the mRNA sequence NM_009019 within exon 2 of 2 total exons. The mutation results in a proline to leucine substitution at position 171 (P171L) in the RAG1 protein. (J:272858)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rag1 Mutation: 120 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4008

References

• Original: J:272858 Zhong X, et al., Mutagenetix entry for dysfunctional. MGI Direct Data Submission. 2019
• All: 1 reference(s)