Itgam^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Itgam^m2Btlr
• Name: integrin alpha M; mutation 2, Bruce Beutler
• MGI ID: MGI:6285545
• Synonyms: obscured
• Gene: Itgam Location: Chr7:127661812-127717663 bp, + strand Genetic Position: Chr7, 69.93 cM, cytoband F4
• Alliance: Itgam^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C to T transition at base pair 128,081,634 (v38) on chromosome 7, or base pair 18,995 in the GenBank genomic region NC_000073. The mutation corresponds to residue 837 in the mRNA sequence NM_001082960 within exon 8 of 30 total exons. The mutation results in an alanine to valine substitution at position 245 (A245V) in the CD11b protein. (J:272532)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgam Mutation: 47 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=3757

References

• Original: J:272532 Zhong X, et al., Mutagenetix entry for obscured. MGI Direct Data Submission. 2019
• All: 1 reference(s)