Dock2^M14Btlr
Chemically induced Allele Detail

Summary

• Symbol: Dock2^M14Btlr
• Name: dedicator of cyto-kinesis 2; mutation 14, Bruce Beutler
• MGI ID: MGI:6285155
• Synonyms: Launch
• Gene: Dock2 Location: Chr11:34176815-34674719 bp, - strand Genetic Position: Chr11, 19.68 cM, cytoband A5
• Alliance: Dock2^M14Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 34,256,562 (v38) on chromosome 11, or base pair 527,348 in the GenBank genomic region NC_000077 for Dock2. The mutation corresponds to residue 4,115 in the mRNA sequence NM_178666 within exon 40 of 52 total exons. The mutation results in a glycine to arginine substitution at position 1,345 (G1345R) in the DOCK2 protein. (J:272438)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock2 Mutation: 142 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4068

References

• Original: J:272438 Zhong X, et al., Mutagenetix entry for Launch. MGI Direct Data Submission. 2019
• All: 1 reference(s)