Dock2^m13Btlr
Chemically induced Allele Detail

Summary

• Symbol: Dock2^m13Btlr
• Name: dedicator of cyto-kinesis 2; mutation 13, Bruce Beutler
• MGI ID: MGI:6285149
• Synonyms: skiff
• Gene: Dock2 Location: Chr11:34176815-34674719 bp, - strand Genetic Position: Chr11, 19.68 cM, cytoband A5
• Alliance: Dock2^m13Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 34,262,388 (v38) on chromosome 11, or base pair 521,522 in the GenBank genomic region NC_000077 for Dock2. The mutation corresponds to residue 3,834 in the mRNA sequence NM_178666 within exon 37 of 52 total exons. The mutation results in a lysine to arginine substitution at position 1,251 (K1251R) in the DOCK2 protein. (J:272437)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock2 Mutation: 142 strains or lines available

Notes

https://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=4069

References

• Original: J:272437 Zhong X, et al., Mutagenetix entry for skiff. MGI Direct Data Submission. 2019
• All: 1 reference(s)