Gsdme^em1Broz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gsdme^em1Broz
• Name: gasdermin E; endonuclease-mediated mutation 1, Petr Broz
• MGI ID: MGI:6285139
• Gene: Gsdme Location: Chr6:50167013-50240837 bp, - strand Genetic Position: Chr6, 24.13 cM
• Alliance: Gsdme^em1Broz page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• CRISPR-targeting introduced a 1 bp insertion in exon 2 that results in a premature stop codon. (J:272519)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdme Mutation: 43 strains or lines available

References

• Original: J:272519 Chen KW, et al., Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly. EMBO J. 2019 Mar 22
• All: 3 reference(s)