Zhx2tm1c(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Zhx2tm1c(KOMP)Wtsi |
Name: |
zinc fingers and homeoboxes 2; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6284309 |
Synonyms: |
Zhx2fl |
Gene: |
Zhx2 Location: Chr15:57558063-57703228 bp, + strand Genetic Position: Chr15, 24.01 cM
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Alliance: |
Zhx2tm1c(KOMP)Wtsi page
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IMPC: |
Zhx2 gene page |
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Mutant Cell Line: |
EPD0245_1_A06 |
Germline Transmission: |
Earliest citation of germline transmission:
J:256166
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 57683948 of Chromosome 15 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon at position 57687497. The critical exon 3 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:256166)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Zhx2 Mutation: |
33 strains or lines available
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Original: |
J:256166 Creasy KT, et al., Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver. Gene Expr. 2016;17(1):7-17 |
All: |
5 reference(s) |
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