Serinc5^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Serinc5^em1(IMPC)J
• Name: serine incorporator 5; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6283655
• Gene: Serinc5 Location: Chr13:92747646-92848455 bp, + strand Genetic Position: Chr13, 47.75 cM
• Alliance: Serinc5^em1(IMPC)J page
• IMPC: Serinc5 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences CCTGTTAGAACTAGGCTGAG and ATAAAACTCTTCTTCACGGT, which resulted in a 441 bp deletion beginning at Chromosome 13 position 92,682,714 bp and ending after 92,683,154 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000304535 (exon 3) and 259 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 65 and early truncation 4 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Serinc5 Mutation: 30 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 2 reference(s)