Wasf3^tm1Jkc
Targeted Allele Detail

Summary

• Symbol: Wasf3^tm1Jkc
• Name: WASP family, member 3; targeted mutation 1, John K Cowell
• MGI ID: MGI:6283616
• Gene: Wasf3 Location: Chr5:146321795-146410425 bp, + strand Genetic Position: Chr5, 85.23 cM
• Alliance: Wasf3^tm1Jkc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283776
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 4, and an FRT-flanked neomycin selection cassette followed by a second loxP site downstream of exon 5 of the gene. (J:283776)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wasf3 Mutation: 37 strains or lines available

References

• Original: J:283776 Qin H, et al., Wasf3 Deficiency Reveals Involvement in Metastasis in a Mouse Model of Breast Cancer. Am J Pathol. 2019 Dec;189(12):2450-2458
• All: 1 reference(s)