Adm^tm1.1Kmca
Targeted Allele Detail

Summary

• Symbol: Adm^tm1.1Kmca
• Name: adrenomedullin; targeted mutation 1.1, Kathleen M Caron
• MGI ID: MGI:6281960
• Synonyms: Adm^3'delta
• Gene: Adm Location: Chr7:110226868-110229027 bp, + strand Genetic Position: Chr7, 57.7 cM
• Alliance: Adm^tm1.1Kmca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206227
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted into the 3' UTR downstream of the translation stop codon contains a loxP site, the bovine growth hormone polyadenylation sequence, 2 tandem copies of the 1.2-kb 5' insulator sequence from chicken beta-globin gene, neomycin resistance cassette, loxP site and 80 bp of AU/U-rich element of the mouse Fos gene. Cre-mediated recombination removed the bovine growth hormone polyadenylation sequence through the neomycin resistance cassette. (J:206227)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adm Mutation: 16 strains or lines available

References

• Original: J:206227 Wetzel-Strong SE, et al., Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis. Dev Dyn. 2014 Feb;243(2):243-56
• All: 1 reference(s)