Wwp1^tm1.1Hkb
Targeted Allele Detail

Summary

• Symbol: Wwp1^tm1.1Hkb
• Name: WW domain containing E3 ubiquitin protein ligase 1; targeted mutation 1.1, Hiroshi Kawabe
• MGI ID: MGI:6281946
• Synonyms: Wwp1^f
• Gene: Wwp1 Location: Chr4:19608303-19708993 bp, - strand Genetic Position: Chr4, 7.56 cM
• Alliance: Wwp1^tm1.1Hkb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269370
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 6 was floxed. Flp-mediated recombination removed the neomycin resistance selection cassette inserted downstream of exon 6. (J:269370)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwp1 Mutation: 64 strains or lines available

References

• Original: J:269370 Ambrozkiewicz MC, et al., Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140. Neuron. 2018 Dec 5;100(5):1097-1115.e15
• All: 3 reference(s)