Jak1^Spade
Spontaneous Allele Detail

Summary

• Symbol: Jak1^Spade
• Name: Janus kinase 1; stepwise, progressive atopic dermatitis
• MGI ID: MGI:6281713
• Gene: Jak1 Location: Chr4:101009564-101122479 bp, - strand Genetic Position: Chr4, 46.19 cM
• Alliance: Jak1^Spade page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Single point mutation
• Mutation details: This allele has a G-to-A missense mutation at coding nucleotide 2633 that results in the amino acid substitution of arginine with histidine at position 878 (p.R878H). (J:237080)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Jak1 Mutation: 51 strains or lines available

References

• Original: J:237080 Yasuda T, et al., Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis. J Clin Invest. 2016 Jun 01;126(6):2064-76
• All: 4 reference(s)