Tg(Eif1a-LUM*L199P,-hrGFP)#Fzha
Transgene Detail

Summary

• Symbol: Tg(Eif1a-LUM*L199P,-hrGFP)#Fzha
• Name: transgene insertion, Fengju Zhang
• MGI ID: MGI:6281657
• Transgene: Tg(Eif1a-LUM*L199P,-hrGFP)#Fzha Location: unknown
• Alliance: Tg(Eif1a-LUM*L199P,-hrGFP)#Fzha page

Transgene origin

• Strain of Origin: C57BL/6 x DBA/2

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(Eif1a-LUM*L199P,-hrGFP)#Fzha expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LUM (4060)

  Lum	(MGI:109347)

  "flag tagged human cDNA with the L199P mutation seen in English myopic patient"

• Mutation details: The transgene contains the elongation factor 1-alpha promoter, human lumican with a T to C mutation at position 596 which results in a leucine to proline substitution at amino acid 199 (L199P) with a FLAG tag, and IRES, and the humanized renilla green fluorescent protein (hrGFP). The L199P mutation was identified in an English myopic patient. (J:250674)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:250674 Song Y, et al., Enlargement of the Axial Length and Altered Ultrastructural Features of the Sclera in a Mutant Lumican Transgenic Mouse Model. PLoS One. 2016;11(10):e0163165
• All: 1 reference(s)