Rabgef1^tm3.1Glli
Targeted Allele Detail

Summary

• Symbol: Rabgef1^tm3.1Glli
• Name: RAB guanine nucleotide exchange factor (GEF) 1; targeted mutation 3.1, Stephen J Galli
• MGI ID: MGI:6281617
• Synonyms: Rabgef1^fl
• Gene: Rabgef1 Location: Chr5:130200644-130243178 bp, + strand Genetic Position: Chr5, 68.78 cM, cytoband F
• Alliance: Rabgef1^tm3.1Glli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239755
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 2 was floxed. Flp-mediated recombination removed the neomycin seletion cassette. (J:239755)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rabgef1 Mutation: 67 strains or lines available

References

• Original: J:239755 Marichal T, et al., Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis. J Clin Invest. 2016 Dec 01;126(12):4497-4515
• All: 2 reference(s)