Mtln^em1Eno
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mtln^em1Eno
• Name: mitoregulin; endonuclease-mediated mutation 1, Eric N Olson
• MGI ID: MGI:6281350
• Gene: Mtln Location: Chr2:127633308-127634408 bp, - strand Genetic Position: Chr2, 62.1 cM
• Alliance: Mtln^em1Eno page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 1 bp deletion and 3 bp insertion in exon 1 that creates a frame-shift and premature stop codon. Western blot analysis confirmed absence of protein in muscle tissues. (J:271253)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtln Mutation: 9 strains or lines available

References

• Original: J:271253 Makarewich CA, et al., MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid beta-Oxidation. Cell Rep. 2018 Jun 26;23(13):3701-3709
• All: 1 reference(s)