Plxna2^em1Rojg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plxna2^em1Rojg
• Name: plexin A2; endonuclease-mediated mutation 1, Roman J Giger
• MGI ID: MGI:6281329
• Synonyms: Plxna2^R, Plxna2^R1746A
• Gene: Plxna2 Location: Chr1:194302020-194499177 bp, + strand Genetic Position: Chr1, 98.27 cM, cytoband H6
• Alliance: Plxna2^em1Rojg page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a CGT to GCC mutation in the GAP domain resulting in an arginine to alanine substitution at amino acid 1746. Western blot analysis shows no difference in protein levels between wild-type and mutant protein in the brain. (J:271262)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plxna2 Mutation: 128 strains or lines available

References

• Original: J:271262 Zhao XF, et al., PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors. Cell Rep. 2018 Jan 9;22(2):456-470
• All: 2 reference(s)