Mtss1^tm1.1Keng
Targeted Allele Detail

Summary

• Symbol: Mtss1^tm1.1Keng
• Name: MTSS I-BAR domain containing 1; targeted mutation 1.1, Mineko Kengaku
• MGI ID: MGI:6281196
• Synonyms: MTSS1^flox
• Gene: Mtss1 Location: Chr15:58813083-58953854 bp, - strand Genetic Position: Chr15, 25.09 cM
• Alliance: Mtss1^tm1.1Keng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271329
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and a second loxP site and a frt-flanked Pgk-1 promoter driven neomycin resistance gene were inserted downstream of exon 4. Flp-mediated recombination removed the neomycin gene leaving exon 4 floxed. (J:271329)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtss1 Mutation: 119 strains or lines available

References

• Original: J:271329 Kawabata Galbraith K, et al., MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells. Cell Rep. 2018 Jul 3;24(1):95-106.e9
• All: 2 reference(s)