Cxcr3^{tm1.1(CXCR3)Cmac}
Targeted Allele Detail

Summary

• Symbol: Cxcr3^{tm1.1(CXCR3)Cmac}
• Name: C-X-C motif chemokine receptor 3; targeted mutation 1.1, Charles R Mackay
• MGI ID: MGI:6281161
• Gene: Cxcr3 Location: ChrX:100775141-100777753 bp, - strand Genetic Position: ChrX, 44.58 cM
• Alliance: Cxcr3^{tm1.1(CXCR3)Cmac} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271263
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cxcr3^{tm1.1(CXCR3)Cmac} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CXCR3 (2833)

  Cxcr3

  (MGI:1277207)

• Mutation details: The coding sequence was replaced with a loxP site, cDNA encoding the human sequence, FRT-flanked neomycin resistance cassette and loxP site. Flp-mediated recombination removed the selection cassette. (J:271263)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcr3 Mutation: 12 strains or lines available

References

• Original: J:271263 Piovesan D, et al., c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses. Cell Rep. 2017 Apr 18;19(3):461-470
• All: 2 reference(s)