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Endonuclease-mediated Allele Detail
Symbol: Grxcr2em1Bzha
Name: glutaredoxin, cysteine rich 2; endonuclease-mediated mutation 1, Bo Zhao
MGI ID: MGI:6281113
Synonyms: Grxcr2D46
Gene: Grxcr2  Location: Chr18:42118388-42132114 bp, - strand  Genetic Position: Chr18, 22.14 cM
Alliance: Grxcr2em1Bzha page
Strain of Origin:  C57BL/6J
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsCRISPR/Cas9 technology generated a 46 bp deletion in exon 1. The frameshift caused by the deletion creates an early stop codon. (J:271271)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grxcr2 Mutation:  13 strains or lines available
Original:  J:271271 Liu C, et al., GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing. Cell Rep. 2018 Oct 30;25(5):1268-1280.e4
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory