Mir191^em2Bds
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir191^em2Bds
• Name: microRNA 191; endonuclease-mediated mutation 2, B David Stollar
• MGI ID: MGI:6281008
• Gene: Mir191 Location: Chr9:108445518-108445591 bp, + strand Genetic Position: Chr9, 59.5 cM
• Alliance: Mir191^em2Bds page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 1 deleted 7 and 15 bp of the critical region resulting in complete loss of the mature transcript. (J:269885)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir191 Mutation: 2 strains or lines available

References

• Original: J:269885 Blume J, et al., miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1. Eur J Immunol. 2019 Jan;49(1):121-132
• All: 1 reference(s)