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Hmgcs1em1(IMPC)J
Endonuclease-mediated Allele Detail
Summary
Symbol: Hmgcs1em1(IMPC)J
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:6280025
Gene: Hmgcs1  Location: Chr13:120151915-120169796 bp, + strand  Genetic Position: Chr13, Syntenic
Alliance: Hmgcs1em1(IMPC)J page
IMPC: Hmgcs1 gene page
Mutation
origin
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TCTACACTGCAAAGAGAGCA and ACTTACTACCTCTCTAGAAC, which resulted in a 548 bp deletion beginning at Chromosome 13 position 119,702,388 bp and ending after 119,702,935 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001063943 (exon 5) and 382 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 246 and early truncation 4 amino acids later. (J:188991)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hmgcs1 Mutation:  18 strains or lines available
References
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory