Apoe^tm1Smoc
Targeted Allele Detail

Summary

• Symbol: Apoe^tm1Smoc
• Name: apolipoprotein E; targeted mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6279808
• Synonyms: APOE^-
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^tm1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270914
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Exons 2-3 were replaced by Neo cassette. (J:270914)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 168 strains or lines available

References

• Original: J:270914 Zhong S, et al., Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation. J Clin Invest. 2019 Jan 2;129(1):252-267
• All: 4 reference(s)