Gsdmd^em10Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gsdmd^em10Gpt
• Name: gasdermin D; endonuclease-mediated mutation 10, GemPharmatech Co., Ltd
• MGI ID: MGI:6279768
• Synonyms: Gsdmd^em10Cd127, Gsdmd^em1Nju
• Gene: Gsdmd Location: Chr15:75734176-75739257 bp, + strand Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
• Alliance: Gsdmd^em10Gpt page

Mutation origin

• Strain of Origin: C57BL/6NGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing was used to generate a 127 bp deletion in exon 3 that results in a frame shift and subsequent introduction of a stop codon 32 condons downstream. qPCR confirmed complete deletion of the mRNA. (J:270873)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdmd Mutation: 35 strains or lines available

References

• Original: J:270873 Kambara H, et al., Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death. Cell Rep. 2018 Mar 13;22(11):2924-2936
• All: 6 reference(s)